Titli：Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing

标题：由新型黑曲霉菌（Pleurostoma hongkongense sp. nov.）引起的肝黑曲霉病及真菌药物敏感性检测的重要性

作者: Tsang C. C., Chan K. F., Chan W., et al.

作者: 曾子聪, 陈国峰, 陈伟, 等

期刊: Emerging Microbes & Infections

期刊: 新兴微生物与感染

出版年: 2020

摘要: 本研究报告了一种新型的黑色真菌（dematiaceous fungus）导致的肝脏着色真菌病（phaeohyphomycosis），该真菌命名为Pleurostoma hongkongense sp. nov.。研究强调了抗真菌药物敏感性测试的重要性，以指导临床治疗。

引言

This study reports a case of hepatic phaeohyphomycosis caused by a novel dematiaceous fungus, named Pleurostoma hongkongense sp. nov. The importance of antifungal susceptibility testing in guiding clinical treatment is emphasized.

本研究报告了一例由一种新型黑色真菌Pleurostoma hongkongense引起的肝脏着色真菌病病例。着色真菌病是一种严重的真菌感染，通常发生在免疫系统受损的患者中。

病例报告

The study describes a patient presenting with hepatic infection. Histological examination and molecular analysis confirmed the pathogen as a novel dematiaceous fungus, named Pleurostoma hongkongense sp. nov.

研究团队描述了一名患者的病例，该患者因肝脏感染而就诊。通过组织学检查和分子生物学分析，确定了感染的病原体为一种新型的黑色真菌。该真菌被命名为Pleurostoma hongkongense sp. nov.

方法

Histopathology, fungal culture, molecular biology (including DNA sequencing), and antifungal susceptibility testing were used to identify the pathogen and determine an effective treatment regimen.

研究采用了组织病理学、真菌培养、分子生物学（包括DNA测序）等方法来鉴定病原体。此外，进行了抗真菌药物敏感性测试，以确定有效的治疗方案。

结果

Pleurostoma hongkongense exhibited varying susceptibilities to different antifungal agents. The fungus showed sensitivity to Amphotericin B and Voriconazole but had higher resistance to other commonly used antifungal drugs.

分离出的Pleurostoma hongkongense表现出对多种抗真菌药物的不同敏感性。研究结果显示，该真菌对两性霉素B、伏立康唑等药物具有一定的敏感性，但对其他一些常用抗真菌药物的耐药性较高。

讨论

The study highlights the importance of antifungal susceptibility testing in treating rare and novel fungal infections. Accurate and timely susceptibility testing can improve treatment outcomes and reduce the risk of treatment failure.

研究强调了抗真菌药物敏感性测试在治疗罕见和新型真菌感染中的重要性。通过及时准确的药物敏感性测试，可以提高治疗效果，减少治疗失败的风险。

结论

This article reports Pleurostoma hongkongense sp. nov. as a pathogenic fungus for the first time and underscores the necessity of antifungal susceptibility testing in managing such rare infections.

这篇文章首次报道了Pleurostoma hongkongense sp. nov.作为致病真菌，并强调了在处理这种罕见感染时进行抗真菌药物敏感性测试的重要性。

相关化合物及CAS号

The following are the antifungal drugs mentioned in the article and their corresponding CAS numbers:

以下是文献中提到的几种抗真菌药物及其对应的CAS号：

1.Amphotericin B (两性霉素B)

CAS号: 1397-89-3

2.Voriconazole (伏立康唑)

CAS号: 137234-62-9

3.Itraconazole (伊曲康唑)

CAS号: 84625-61-6

4.Posaconazole (泊沙康唑)

CAS号: 171228-49-2

5.Caspofungin (卡泊芬净)

CAS号: 179463-17-3

6.Micafungin (米卡芬净)

CAS号: 235114-32-6

7.Anidulafungin (阿尼芬净)

CAS号: 166663-25-8

8.Fluconazole (氟康唑)

CAS号: 86386-73-4