Authors: Tomoharu Kono, et al.

作者: 河野友治 等

Journal: Molecular and Cellular Biochemistry

期刊: 分子与细胞生物化学

Publication Date: April 2008

出版日期: 2008年4月

Volume and Issue: Volume 311, Issue 1-2, Pages 87-92

卷和期: 第311卷，第1-2期，87-92页

Abstract: This study investigates the effects of sivelestat sodium hydrate, a neutrophil elastase inhibitor, on ischemia-reperfusion injury in the rat bladder. Ischemia-reperfusion injury is a common issue that can cause significant damage to various tissues, including the bladder. The study demonstrates that sivelestat sodium hydrate can mitigate this damage by inhibiting neutrophil elastase, thereby reducing inflammation and tissue injury.

摘要: 本研究探讨了中性粒细胞弹性蛋白酶抑制剂Sivelestat钠水合物对大鼠膀胱缺血再灌注损伤的影响。缺血再灌注损伤是一个常见问题，会对包括膀胱在内的多种组织造成重大损害。研究表明，Sivelestat钠水合物可以通过抑制中性粒细胞弹性蛋白酶来减轻这种损伤，从而减少炎症反应和组织损伤。

Key Findings:

• Sivelestat sodium hydrate effectively reduces bladder tissue damage caused by ischemia-reperfusion.
• The inhibition of neutrophil elastase leads to decreased inflammatory response and tissue protection.

主要发现:

• Sivelestat钠水合物有效减少了缺血再灌注引起的膀胱组织损伤。
• 抑制中性粒细胞弹性蛋白酶可降低炎症反应并保护组织。

相关化合物及CAS号

1.Sivelestat Sodium Hydrate (Sivelestat钠水合物)

CAS号: 130285-88-6

2.Neutrophil Elastase (中性粒细胞弹性蛋白酶)

CAS号: 9004-06-2

3.High Mobility Group Box 1 (HMGB1蛋白)

CAS号: 123773-61-1