Title：Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin

标题：莰烯诱导人原代真皮成纤维细胞增殖和抗衰老活性，并抑制小鼠皮肤紫外线诱导的皱纹形成

Authors: Tran TA, Hoang DM, Park C, Lee WH, Park S, Yang M, Jang J, Park J, Kang JH, Jung D

Journal: Phytotherapy Research

Publication Date: December 2015

Volume: 29

Issue: 12

Pages: 1917-1925

DOI: 10.1002/ptr.5487

Abstract:

This study examines the effects of camphor on human primary dermal fibroblasts and mouse skin exposed to UV radiation. Camphor was found to induce cell proliferation and exhibit anti-senescence activities. In mouse skin, camphor application reduced wrinkle formation induced by UV exposure. The study highlights the potential of camphor as an active ingredient in anti-aging skincare formulations.

摘要：

本研究探讨了樟脑对人类初级真皮成纤维细胞和暴露于紫外线辐射的小鼠皮肤的影响。研究发现，樟脑能够诱导细胞增殖并表现出抗衰老活性。在小鼠皮肤中，樟脑的应用减少了紫外线诱导的皱纹形成。该研究强调了樟脑作为抗衰老护肤品活性成分的潜力。

Key Findings:

1. Cell Proliferation: Camphor significantly increased the proliferation of human primary dermal fibroblasts.
2. Anti-senescence: It reduced senescence markers in these cells.
3. Collagen and Elastin Production: Camphor enhanced the production of collagen and elastin, crucial components for skin elasticity and firmness.
4. UV Protection: In mice, camphor application reduced UV-induced wrinkle formation by decreasing matrix metalloproteinase-1 (MMP-1) levels and increasing collagen and elastin levels.

主要发现：

1. 细胞增殖： 樟脑显著增加了人类初级真皮成纤维细胞的增殖。
2. 抗衰老： 它减少了这些细胞中的衰老标志物。
3. 胶原蛋白和弹性蛋白生产： 樟脑增强了胶原蛋白和弹性蛋白的生产，这是皮肤弹性和紧致的重要组成部分。
4. 紫外线保护： 在小鼠中，樟脑的应用通过减少基质金属蛋白酶-1 (MMP-1) 水平和增加胶原蛋白和弹性蛋白水平，减少了紫外线诱导的皱纹形成。

Methodology:

• In vitro studies: Human primary dermal fibroblasts were treated with various concentrations of camphor, and cell proliferation and senescence markers were measured.
• In vivo studies: Mice were exposed to UV radiation and treated with camphor to assess its effect on wrinkle formation and collagen/elastin production.

方法学：

• 体外研究： 用不同浓度的樟脑处理人类初级真皮成纤维细胞，测量细胞增殖和衰老标志物。
• 体内研究： 小鼠暴露于紫外线辐射并用樟脑处理，以评估其对皱纹形成和胶原蛋白/弹性蛋白生产的影响。

相关CAS号：

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