Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice

Authors / 作者:

Uchida NS et al. / 内田NS等

Journal / 期刊:

Evidence-Based Complementary and Alternative Medicine, 2017 / 循证补充与替代医学，2017

Abstract / 摘要

This study investigates the hepatoprotective effect of citral on acetaminophen (APAP)-induced liver toxicity in mice. The experiments demonstrated that citral significantly reduces liver injury markers caused by APAP, including serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Additionally, citral protects the liver through antioxidant and anti-inflammatory mechanisms, reducing hepatic oxidative stress and inflammation.

本研究探讨了柠檬醛（Citral）对扑热息痛（Acetaminophen，APAP）诱导的小鼠肝脏毒性的保护作用。实验表明，柠檬醛能够显著降低由APAP引起的肝脏损伤指标，包括血清中丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的水平。此外，柠檬醛通过抗氧化和抗炎机制，减少肝脏氧化应激和炎症反应，从而保护肝脏。

Methods / 实验方法

1. Animal experiments: Mice were divided into groups and treated with different doses of citral and APAP.
2. Biochemical analysis: Serum levels of ALT and AST were measured to assess liver injury.
3. Histological examination: Liver tissues were stained with hematoxylin and eosin (H&E) to observe pathological changes.
4. Antioxidant assays: Hepatic levels of glutathione (GSH) and superoxide dismutase (SOD) were measured.

1. 动物实验：小鼠被分为多组，分别接受不同剂量的柠檬醛和APAP处理。
2. 生化分析：检测血清中ALT和AST水平，评估肝脏损伤。
3. 组织学检查：通过苏木精-伊红染色（H&E）观察肝组织的病理变化。
4. 抗氧化测定：检测肝脏中的谷胱甘肽（GSH）和超氧化物歧化酶（SOD）等抗氧化指标。

Results / 结果

- Citral significantly reduced APAP-induced ALT and AST levels, indicating its hepatoprotective effect.
- Histological examination showed that citral reduced hepatocyte necrosis and inflammatory infiltration.
- Citral increased hepatic levels of GSH and SOD, reducing oxidative stress.

- 柠檬醛显著降低了APAP诱导的ALT和AST水平，表明其具有保护肝脏的作用。
- 组织学检查显示柠檬醛减少了肝细胞坏死和炎症浸润。
- 柠檬醛增加了肝脏中GSH和SOD的含量，减少了氧化应激。

Conclusion / 结论

Citral significantly reduces APAP-induced liver damage through its antioxidant and anti-inflammatory effects, demonstrating its potential hepatoprotective properties.

柠檬醛通过抗氧化和抗炎作用，显著减轻了APAP诱导的肝脏损伤，具有潜在的肝脏保护作用。

Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice

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