Title：Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers

标题：营养补充剂对健康志愿者口服后泊沙康唑药代动力学的影响

Authors: Sansone-Parsons A, Krishna G, Calzetta A, Wexler D, Kantesaria B, Rosenberg MA, Saltzman MA

作者: Sansone-Parsons A, Krishna G, Calzetta A, Wexler D, Kantesaria B, Rosenberg MA, Saltzman MA

Journal: Antimicrobial Agents and Chemotherapy

期刊: 抗微生物剂与化疗学

Published: May 2006; Volume 50, Issue 5, Pages 1881-1883

出版时间: 2006年5月；第50卷，第5期，1881-1883页

DOI: 10.1128/AAC.50.5.1881-1883.2006

Abstract

The study evaluates the effect of a nutritional supplement (Boost Plus) on the pharmacokinetics of posaconazole in healthy volunteers. The findings indicate that co-administration with Boost Plus significantly enhances the maximum serum concentration and overall exposure of posaconazole compared to fasting conditions.

摘要

该研究评估了营养补充剂（Boost Plus）对健康志愿者曲安奈德药代动力学的影响。结果表明，与空腹条件相比，联合服用Boost Plus显著增加了曲安奈德的最大血清浓度和总体暴露量。

Introduction

Posaconazole is an antifungal agent used for the treatment of various fungal infections. This study investigates whether the presence of a nutritional supplement affects the absorption and bioavailability of posaconazole.

引言

曲安奈德是一种用于治疗各种真菌感染的抗真菌剂。本研究探讨了营养补充剂的存在是否影响曲安奈德的吸收和生物利用度。

Methods

• Subjects: Healthy volunteers participated in the study.
• Design: The study employed a crossover design where each volunteer received posaconazole with and without the nutritional supplement.
• Measurements: Blood samples were collected at various time points to measure posaconazole serum concentrations.

方法

• 受试者: 健康志愿者参与了本研究。
• 设计: 研究采用交叉设计，每位志愿者在有和没有营养补充剂的情况下服用曲安奈德。
• 测量: 在不同时间点采集血样以测量曲安奈德的血清浓度。

Results

• Pharmacokinetics: The results showed that the nutritional supplement significantly increased both the maximum serum concentration (C_max) and the area under the concentration-time curve (AUC) of posaconazole.
• Implications: The enhanced absorption suggests that taking posaconazole with a high-fat meal or nutritional supplement could improve its efficacy.

结果

• 药代动力学: 结果显示，营养补充剂显著增加了曲安奈德的最大血清浓度（C_max）和浓度-时间曲线下面积（AUC）。
• 影响: 增强的吸收表明，与高脂肪膳食或营养补充剂一起服用曲安奈德可能会提高其疗效。

Discussion

The study suggests that the bioavailability of posaconazole is significantly improved when taken with a nutritional supplement. This finding could influence the recommended administration guidelines for posaconazole to optimize its therapeutic effects.

讨论

研究表明，联合营养补充剂显著提高了曲安奈德的生物利用度。这一发现可能会影响曲安奈德的推荐服用指南，以优化其治疗效果。

Conclusion

Co-administration of posaconazole with a nutritional supplement substantially increases its bioavailability, indicating that dietary factors should be considered to enhance the drug's efficacy.

结论

与营养补充剂联合服用曲安奈德显著提高了其生物利用度，表明应考虑膳食因素以增强药物的疗效。

Compounds and CAS Numbers

Posaconazole (曲安奈德): CAS 171228-49-2