BMS-1|1675201-83-8|(PD-1/PD-L1 inhibitor 1)-陌孚医药/Medlife

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BMS-1 (Synonyms: PD-1/PD-L1 inhibitor 1)

目录号: PL08984 纯度: ≥99%

CAS No. :1675201-83-8

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PL08984-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1632.00	请登录

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中文名称	BMS-1
中文别名	PD-L1 抑制剂1;(S)-1-(2,6-二甲氧基-4-((2-甲基-[1,1'-联苯]-3-基)甲氧基)苄基)哌啶-2-甲酸;(2S)-1-[[2,6-二甲氧基-4-[(2-甲基[1,1'-联苯]-3-基)甲氧基]苯基]甲基]-2-哌啶羧酸
英文名称	BMS-1
英文别名	PD-L1 inhibitor 1;PD1-PDL1 inhibitor 1;PD-1;Pd-1/pd-l1 inhibitor 1;BMS-1;(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;pd-1-pd-l1-inhibitor-1;PD-1/PD-L1 inhibitor 1(C1);BDBM50091334;s7911;PD-1/PD-L1 inhibitor 1;PD1-PDL1 inhibitor 1;Sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide;(2S)-1-[[2,6
Cas No.	1675201-83-8
分子式	C₂₉H₃₃NO₅
分子量	475.58
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	BMS-1 是 PD-1/PD-L1 蛋白质/蛋白质相互作用的抑制剂，IC₅₀ 为 6 到 100 nM。
生物活性	BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC 50 between 6 and 100 nM).
性状	Solid
IC50 & Target[1][2]	PD1-PDL1
体外研究(In Vitro)	Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1. BMS-1, a small-molecule immune checkpoint inhibitor of PD-1/PD-L1, can be used as a therapeutic strategy for tumor immunotherapy. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	BMS-1 (500 μg/mL; 100 μL; i.p.) significantly increases the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Zhao Y, et al. Depression Promotes Hepatocellular Carcinoma Progression through a Glucocorticoids Mediated Up-Regulation of PD-1 Expression in Tumor infiltrating NK Cells. Carcinogenesis. 2019 Feb 4. [2]. Li K, et al. Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy. J Drug Target. 2019 Mar;27(3):244-256.

溶解度数据	In Vitro: Methanol : 25 mg/mL (52.57 mM; Need ultrasonic)DMSO : 9 mg/mL (18.92 mM; Need ultrasonic and warming)DMF : 5 mg/mL (10.51 mM; Need ultrasonic)

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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